All pre-existing treatment of melasma aim at reducing the formation of melanin by the melanocytes (Topical agents) and eliminating pre-existing melanin pigment (peeling, IPL, Lasers).

However, they inevitably activate melanocytes to form and accumulate abnormal melanin because of inherent irritation, inflammation or by injuries to keratinocytes that may lead to recurrence or post inflammatory hyperpigmentation (PIH).

All pre-existing treatment of melasma aim at reducing the formation of melanin by the melanocytes (Topical agents) and eliminating pre-existing melanin pigment (peeling, IPL, Lasers). However, they inevitably activate melanocytes to form and accumulate abnormal melanin because of inherent irritation, inflammation or by injuries to keratinocytes that may lead to recurrence or post inflammatory hyperpigmentation (PIH).