Atopic Dermatitis or Eczema (Hika sa Balat)

Atopic dermatitis (AD) could be considered as a barrier disease in which antigens and irritants that permeate the skin trigger and worsen the dermatitis. It has been speculated that the impaired barrier function of the skin in AD results from the decreased production of ceramides.

Taken together, the observed clinical efficacy of synthetic lipids, focusing on moisture replenishment and improving the ceramide profile, provides a deep insight into the pathogenesis of AD as a ceramide-deficient disease in which barrier and moisture retaining function is markedly attenuated and predisposes the skin to cutaneous inflammation.