Atopic dermatitis (AD) could be considered as a barrier disease in which antigens and irritants that permeate the skin trigger and worsen the dermatitis. It has been speculated that the impaired barrier function of the skin in AD results from the decreased production of ceramides.
Taken together, the observed clinical efficacy of synthetic lipids, focusing on moisture replenishment and improving the ceramide profile, provides a deep insight into the pathogenesis of AD as a ceramide-deficient disease in which barrier and moisture retaining function is markedly attenuated and predisposes the skin to cutaneous inflammation.
The skin barrier is the outermost layer of your skin’s surface. It consists of dead skin cells and lipids (oils) specifically- ceramides, cholesterol and free fatty acids. The skin barrier is responsible for making sure essential water and electrolytes don’t evaporate from skin. It also serves as a protective shield against harmful microorganisms by producing antimicrobial peptides and proteins.
Also, the skin barrier helps sustain skin’s immunity, and it regulates inflammation. When the skin barrier is perturbed, the skin will be prone to dryness, irritation, infections, and other symptoms you’d attribute to having sensitive skin.
Seborrheic dermatitis or seborrhea is a very common scalp condition that occurs when our scalp’s renewal process is shortened, this leads to the rapid shedding of our scalp’s dead skin cells, forming visible flakes.
A microorganism, Malassezia globosa, which thrives on the natural lipids (oils) of our scalp, triggers the process. It irritates our scalp, causing micro-inflammations, scalp itchiness, redness, and dandruff.